| Summary: | Lycium barbarum polysaccharides (LBP) has been reported to possess abundant bioactive activities, such as anti-cancer, antioxidant activities, anti-diabetes, immune function and anti-fatigue, however, whether it can influence the healthy adults, especially at metabolomics level is still unclear. Therefore, metabolomics effects of LBP on adults were investigated in the present study. 42 males were randomly divided into LBP supplementation (300 mg/d) and control group for 4 weeks, followed by anthropometric, biochemical indexes, and metabolic profiles detection. LBP was determined with 3.74 kDa, consisted of fucose, rhamnose, amino-galactose, galactose, glucose, mannose and fructose with a molar ratio of 0.02:0.08:0.03:0.11:46.67:0.37:4.72. Dietary LBP supplementation decreased the TG/HDL index significantly. d-talose decreased, phosphate and leucine increased significantly in serum. 4-Hydroxymandelonitrile 1 increased, and tyrosine 1, 3-Aminoisobutyric acid 1, threitol and ribose decreased significantly in urine. Eight metabolites were simultaneously assessed by indicating the glycerophospholipid metabolism and tyrosine metabolism after LBP supplementation in males.
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