Adenosine Receptors and Wound Healing, Revised

Adenosine Receptors and Wound Healing, Revised

Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adeno...

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Main Author: Bruce M. Cronstein
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2006.194
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spelling doaj-9be3031b67884ac6a7bd982941e6fe592020-11-24T21:48:03ZengHindawi LimitedThe Scientific World Journal1537-744X2006-01-01698499110.1100/tsw.2006.194Adenosine Receptors and Wound Healing, RevisedBruce M. Cronstein0Department of Medicine, Pathology and Pharmacology, New York University School of Medicine, New York, NY 10016, USARecent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. Here we summarize the evidence indicating that adenosine and selective adenosine agonists, acting at A2A receptors, promote the salutary functions of inflammatory cells, endothelial cells and fibroblasts in stimulating wound healing.http://dx.doi.org/10.1100/tsw.2006.194
collection DOAJ
language English
format Article
sources DOAJ
author Bruce M. Cronstein
spellingShingle Bruce M. Cronstein
Adenosine Receptors and Wound Healing, Revised
The Scientific World Journal
author_facet Bruce M. Cronstein
author_sort Bruce M. Cronstein
title Adenosine Receptors and Wound Healing, Revised
title_short Adenosine Receptors and Wound Healing, Revised
title_full Adenosine Receptors and Wound Healing, Revised
title_fullStr Adenosine Receptors and Wound Healing, Revised
title_full_unstemmed Adenosine Receptors and Wound Healing, Revised
title_sort adenosine receptors and wound healing, revised
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2006-01-01
description Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. Here we summarize the evidence indicating that adenosine and selective adenosine agonists, acting at A2A receptors, promote the salutary functions of inflammatory cells, endothelial cells and fibroblasts in stimulating wound healing.
url http://dx.doi.org/10.1100/tsw.2006.194
work_keys_str_mv AT brucemcronstein adenosinereceptorsandwoundhealingrevised
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