Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3′-untranslated region

Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3′-untranslated region

The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′-UTR)....

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Bibliographic Details
Main Authors: D.N. Piranda, R.B.V. Abreu, D.R. Freitas-Alves, M.A. de Carvalho, R. Vianna-Jorge
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2017-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
COX-2
PTGS2
Haplotypes
Gene expression
MCF-7
HEK293FT
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200602&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200602&lng=en&tlng=en

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