The predictive role of interim pet-ct in the treatment of hodgkin's lymphoma in children

• Main Authors: N S Kulichkina, E S Belyaeva, A V Popa, T T Valiev, A A Odzharova, G L Mentkevich
• Format: Article
• Language: Russian
• Published: IP Habib O.N. 2017-09-01
• Series: Современная онкология
• Subjects: hodgkin's lymphoma (hl); positron emission tomography (pet); deauville five-point scale; semiquantitative assessment of pet-ct
• Online Access: https://modernonco.orscience.ru/1815-1434/article/viewFile/27152/pdf

Propose - to estimate a role of the interim PET-CT using 2 methods: visual (Deauville scale) and semiquantitative (calculation of the standard uptake value - SUV). Methods. The results of PET-CT of 40 children with the Hodgkin's lymphoma (HL) received treatment since June, 2012 to September, 2016 were analysed. 37 patients - with newly diagnosed HL, 2 - with a recurrence and 1 - with a refractory HL entered into this group. Patients received therapy under protocols of treatment of HL, proved in the Institute of Pediatric Oncology and Hematology N.N.Blokhin National Medical Reseach Center of Oncology, depending on the status and a stage of a disease. In addition to the traditional study techniques (TRT) - ultrasonic investigation (ultrasonography), a computer tomography with i.v. gain (KT), the magnetic resonance imaging (MRI), to all patients was three times executed by PET-CT at various stages of therapy: before treatment, during therapy and after completion of the program chemotherapy. All studies were executed in alone PET center in NMIC of N.N.Blochin. Results. The sensitivity and specificity of the intermediate PET-CT were 100% and 73% while the sensitivity of TMI at the intermediate stage of treatment was 50%, specificity of 79%. Assessment 3 points on Deauville scale (a visual method) at a stage of the intermediate PET-research demonstrates sensitivity of a tumor to the carried-out chemotherapy and does not demand strengthening of intensity of treatment, even on condition of existence of a residual tumor. Conclusion. At the choice of a method of assessment of results of PET preference should be given to a visual method with use of the Deauville five-point scale.