Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies

Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies

Abstract Background Systematic technical effects—also called batch effects—are a considerable challenge when analyzing DNA methylation (DNAm) microarray data, because they can lead to false results when confounded with the variable of interest. Methods to correct these batch effects are error-prone,...

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Bibliographic Details
Main Authors: Tristan Zindler, Helge Frieling, Alexandra Neyazi, Stefan Bleich, Eva Friedel
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Bioinformatics
Subjects:
DNA methylation
Simulation
EPIC array
450 K array
Illumina
Batch effects
Online Access:http://link.springer.com/article/10.1186/s12859-020-03559-6

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