| Summary: | Over time a wide range of changes occur within the skin and make up the phenomenon of its aging. It isa composite, multiform-type process all aspects of which have not been exactly learnt yet. This phenomenonis a comprehensive result of a natural, internal process of aging, mass of UV-radiation dose (photoaging), influenceof different environmental factors and also the deficiency of genital hormones, which in the case ofwomen at the age of around 50 is defined as menopause.Hormonal replacement therapy involves supply of feminine genital hormones for minimising of menopausesymptoms and prevention of remote consequences. HRT significantly affects subjective self-assessment of theskin condition by women in menopause and changes some biophysical properties of the skin surface. Aims: to demonstrate changes to some biophysical properties of the skin affected by hormonal replacementtherapy and compare them with subjective self-assessment of the skin condition by women in menopause. Methods: Measurements of the biophysical properties of skin surface (sebumetry, corneometry, pH-metry, mexametryand TEWL); questionnaire of subjective self-assessment of the skin condition by women in menopause. Results: Hormonal replacement therapy affects some biophysical properties of the skin surface. HRT increasedthe sebum level, water content, decreased erythema of the skin and reduced the transepidermal waterloss (TEWL). The level of melanin within skin grows due to the feminine hormone genital application. Subjectiveself-assessment of the skin condition by women in menopause does not correlate with results of measurementsof biophysical properties of the skin surface. Conclusions: Hormonal replacement therapy changes some biophysical properties of the skin surface andconsiderably improves appearance and functions of the skin of women in menopause. Women using hormonalreplacement therapy perceive worse condition of skin in comparison to women without HRT.
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