Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

Abstract Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above backgroun...

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Bibliographic Details
Main Authors:	M. Rebecca Glineburg, Yuan Zhang, Amy Krans, Elizabeth M. Tank, Sami J. Barmada, Peter K. Todd
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Series:	Acta Neuropathologica Communications
Subjects:	C9orf72 Amyotrophic lateral sclerosis Fragile X FXTAS Repeat-associated non-AUG (RAN) translation RNA Gelation
Online Access:	https://doi.org/10.1186/s40478-021-01169-8

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