Vascular disrupting agent drug classes differ in effects on the cytoskeleton.

Vascular disrupting agent drug classes differ in effects on the cytoskeleton.

Vascular disrupting agents (VDAs), anti-cancer drugs that target established tumor blood vessels, fall into two main classes: microtubule targeting drugs, exemplified by combretastatin A4 (CA4), and flavonoids, exemplified by 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Both classes increase permea...

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Bibliographic Details
Main Authors: Sujeong Kim, Leonid Peshkin, Timothy J Mitchison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404093?pdf=render

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