Rigorous assessment and integration of the sequence and structure based features to predict hot spots

Rigorous assessment and integration of the sequence and structure based features to predict hot spots

<p>Abstract</p> <p>Background</p> <p>Systematic mutagenesis studies have shown that only a few interface residues termed hot spots contribute significantly to the binding free energy of protein-protein interactions. Therefore, hot spots prediction becomes increasingly i...

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Bibliographic Details
Main Authors: Wang Yong, Wu Di, Yang Sixiao, Chen Wenjing, Chen Ruoying, Tian Yingjie, Shi Yong
Format: Article
Language:English
Published: BMC 2011-07-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/12/311

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