Genome duplications of early vertebrates as a possible chronicle of the evolutionary history of the neural crest

• Main Author: Hiroshi Wada, Kaz Makabe
• Format: Article
• Language: English
• Published: Ivyspring International Publisher 2006-01-01
• Series: International Journal of Biological Sciences
• Online Access: http://www.biolsci.org/v02p0133.htm

<p>It is now accepted that ancestral vertebrates underwent two rounds of genome duplication. Here we test the possible utility of these genome duplication events as a reference time for the evolutionary history of vertebrates, by tracing the molecular evolutionary history of the genes involved in vertebrate neural crest development. For most transcription factors that are involved in neural crest specification, more than two paralogs are involved in that process. These were likely involved in the specification of the neural crest before the genome duplications occurred in ancestral vertebrates, although <i>FoxD</i>3 may have acquired that role after the genome duplications. By contrast, the epithelial-mesenchymal transition of neural crest cells is controlled by genes that evolved after the genome duplications, such as <i>cadherin6</i>, <i>cadherin7</i>, <i>cadherin11</i>, and <i>rhoB</i>. This suggests that primitive neural crest cells control their delamination by using a small or distinct set of cell adhesion molecules. Alternatively, these observations suggest that delamination of the neural crest evolved after the genome duplications. In that case, the neural crest might have evolved in sequential steps; the specification of the neural crest occurred before the genome duplications, and the neural crest acquired a new cell migration property after the genome duplications.</p>