Reporter Cell Assessment of TLR4-Induced NF-κB Responses to Cell-Free Hemoglobin and the Influence of Biliverdin

Reporter Cell Assessment of TLR4-Induced NF-κB Responses to Cell-Free Hemoglobin and the Influence of Biliverdin

Hemoglobin (Hb) released during red blood cell lysis can initiate TLR4-dependent signaling and trigger NF-κB activation in surrounding cells. Observations of chronic bleeding in various cancers leads us to hypothesize that Hb and Hb degradation products released from lysed RBC near cancer n...

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Bibliographic Details
Main Authors: Jill Sharma, Taylor Boyd, Claudia Alvarado, Edwin Gunn, Jaimie Adams, Traci Ness, Robert Dunwoody, John Lamb, Brittany House, James Knapp, Ronald Garner
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Biomedicines
Subjects:
NF-kB
hemoglobin
toll-like receptor 4
cancer
reporter cells
immune regulation
Online Access:https://www.mdpi.com/2227-9059/7/2/41

Internet

https://www.mdpi.com/2227-9059/7/2/41

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