Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy
Food allergy is an increasing public health problem. In a genome-wide scan of children diagnosed by oral food challenge, Marenholz et al. find new genetic associations underlying food allergy, implicating the immune system and the epithelial barrier.
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Nature Publishing Group
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01220-0 |
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doaj-9babf9e0239a43b69d6b7286939ba9972021-05-11T07:56:10ZengNature Publishing GroupNature Communications2041-17232017-10-018111010.1038/s41467-017-01220-0Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergyIngo Marenholz0Sarah Grosche1Birgit Kalb2Franz Rüschendorf3Katharina Blümchen4Rupert Schlags5Neda Harandi6Mareike Price7Gesine Hansen8Jürgen Seidenberg9Holger Röblitz10Songül Yürek11Sebastian Tschirner12Xiumei Hong13Xiaobin Wang14Georg Homuth15Carsten O. Schmidt16Markus M. Nöthen17Norbert Hübner18Bodo Niggemann19Kirsten Beyer20Young-Ae Lee21Max-Delbrück-Center (MDC) for Molecular MedicineMax-Delbrück-Center (MDC) for Molecular MedicineMax-Delbrück-Center (MDC) for Molecular MedicineMax-Delbrück-Center (MDC) for Molecular MedicineDepartment of Allergy, Pulmonology and Cystic Fibrosis, Children’s Hospital, Goethe UniversityDepartment of Pediatric Pneumology and Allergology, Wangen HospitalDepartment of Pediatric Pneumology and Allergology, Wangen HospitalDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical SchoolDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical SchoolDepartment of Pediatric Pneumology and Allergology, Neonatology and Intensive Care, Medical Campus of University OldenburgDepartment of Pediatrics and Adolescent Medicine, Sana Klinikum LichtenbergDepartment of Pediatric Pneumology and Immunology, Charité University Medical CenterDepartment of Pediatric Pneumology and Immunology, Charité University Medical CenterDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public HealthDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public HealthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University GreifswaldInstitute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine GreifswaldInstitute of Human Genetics and Department of Genomics, Life & Brain Center, University of BonnMax-Delbrück-Center (MDC) for Molecular MedicineDepartment of Pediatric Pneumology and Immunology, Charité University Medical CenterDepartment of Pediatric Pneumology and Immunology, Charité University Medical CenterMax-Delbrück-Center (MDC) for Molecular MedicineFood allergy is an increasing public health problem. In a genome-wide scan of children diagnosed by oral food challenge, Marenholz et al. find new genetic associations underlying food allergy, implicating the immune system and the epithelial barrier.https://doi.org/10.1038/s41467-017-01220-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ingo Marenholz Sarah Grosche Birgit Kalb Franz Rüschendorf Katharina Blümchen Rupert Schlags Neda Harandi Mareike Price Gesine Hansen Jürgen Seidenberg Holger Röblitz Songül Yürek Sebastian Tschirner Xiumei Hong Xiaobin Wang Georg Homuth Carsten O. Schmidt Markus M. Nöthen Norbert Hübner Bodo Niggemann Kirsten Beyer Young-Ae Lee |
| spellingShingle |
Ingo Marenholz Sarah Grosche Birgit Kalb Franz Rüschendorf Katharina Blümchen Rupert Schlags Neda Harandi Mareike Price Gesine Hansen Jürgen Seidenberg Holger Röblitz Songül Yürek Sebastian Tschirner Xiumei Hong Xiaobin Wang Georg Homuth Carsten O. Schmidt Markus M. Nöthen Norbert Hübner Bodo Niggemann Kirsten Beyer Young-Ae Lee Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy Nature Communications |
| author_facet |
Ingo Marenholz Sarah Grosche Birgit Kalb Franz Rüschendorf Katharina Blümchen Rupert Schlags Neda Harandi Mareike Price Gesine Hansen Jürgen Seidenberg Holger Röblitz Songül Yürek Sebastian Tschirner Xiumei Hong Xiaobin Wang Georg Homuth Carsten O. Schmidt Markus M. Nöthen Norbert Hübner Bodo Niggemann Kirsten Beyer Young-Ae Lee |
| author_sort |
Ingo Marenholz |
| title |
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy |
| title_short |
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy |
| title_full |
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy |
| title_fullStr |
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy |
| title_full_unstemmed |
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy |
| title_sort |
genome-wide association study identifies the serpinb gene cluster as a susceptibility locus for food allergy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
Food allergy is an increasing public health problem. In a genome-wide scan of children diagnosed by oral food challenge, Marenholz et al. find new genetic associations underlying food allergy, implicating the immune system and the epithelial barrier. |
| url |
https://doi.org/10.1038/s41467-017-01220-0 |
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