A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain injuries and deliver therapeutic or diagnostic pay...
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Nature Publishing Group
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11980 |
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doaj-9ba4b22334aa479f94061528573359012021-05-11T11:21:44ZengNature Publishing GroupNature Communications2041-17232016-06-017111110.1038/ncomms11980A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuriesAman P. Mann0Pablo Scodeller1Sazid Hussain2Jinmyoung Joo3Ester Kwon4Gary B. Braun5Tarmo Mölder6Zhi-Gang She7Venkata Ramana Kotamraju8Barbara Ranscht9Stan Krajewski10Tambet Teesalu11Sangeeta Bhatia12Michael J. Sailor13Erkki Ruoslahti14Cancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteDepartment of Chemistry and Biochemistry, University of California, San DiegoBroad Institute of Harvard and MITCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteLaboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of TartuCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteLaboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of TartuBroad Institute of Harvard and MITDepartment of Chemistry and Biochemistry, University of California, San DiegoCancer Research Center, Sanford Burnham Prebys Medical Discovery InstituteAccurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain injuries and deliver therapeutic or diagnostic payload.https://doi.org/10.1038/ncomms11980 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aman P. Mann Pablo Scodeller Sazid Hussain Jinmyoung Joo Ester Kwon Gary B. Braun Tarmo Mölder Zhi-Gang She Venkata Ramana Kotamraju Barbara Ranscht Stan Krajewski Tambet Teesalu Sangeeta Bhatia Michael J. Sailor Erkki Ruoslahti |
| spellingShingle |
Aman P. Mann Pablo Scodeller Sazid Hussain Jinmyoung Joo Ester Kwon Gary B. Braun Tarmo Mölder Zhi-Gang She Venkata Ramana Kotamraju Barbara Ranscht Stan Krajewski Tambet Teesalu Sangeeta Bhatia Michael J. Sailor Erkki Ruoslahti A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries Nature Communications |
| author_facet |
Aman P. Mann Pablo Scodeller Sazid Hussain Jinmyoung Joo Ester Kwon Gary B. Braun Tarmo Mölder Zhi-Gang She Venkata Ramana Kotamraju Barbara Ranscht Stan Krajewski Tambet Teesalu Sangeeta Bhatia Michael J. Sailor Erkki Ruoslahti |
| author_sort |
Aman P. Mann |
| title |
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| title_short |
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| title_full |
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| title_fullStr |
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| title_full_unstemmed |
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| title_sort |
peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-06-01 |
| description |
Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain injuries and deliver therapeutic or diagnostic payload. |
| url |
https://doi.org/10.1038/ncomms11980 |
| work_keys_str_mv |
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