Functional outcomes of rheumatoid arthritis during various proceduresof anti-inflammatory therapy

• Main Authors: Natalya Vladimirovna Chichasova, S A Vladimirov, G R Imametdinova, E V Igolkina, E L Nasonov
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2010-04-01
• Series: Научно-практическая ревматология
• Subjects: rheumatoid arthritis; treatment; functional outcome
• Online Access: https://rsp.mediar-press.net/rsp/article/view/1252

Objective. To study the functional outcomes of rheumatoid arthritis (RA) 1, 3, 5, and 8 years after use of various procedures of anti-inflammatory therapy. Subjects and methods. One hundred patients with valid RA were examined. The patients were divided into 3 groups: 1) 38 patients received basic anti-inflammatory drugs (BAIDs) only; 2) 37 patients took BAIDs in combination with glucocorticoids (GCs); 3) 25 patients had synchronous programmed intensive therapy. Results. The early use of therapy with BAIDs without GCs in controlled therapy allows functional outcome improvement in patients in RA to greater extent. No therapy control leads to functional outcome worsening in RA. During a long follow-up, there is a reduction in the correlation of the Health Assessment Questionnaire (HAQ) scores with the parameters reflecting disease activity and an increase in the correlation of the HAQ with those reflecting the progression of RA. The development of the structural and anatomic changes in hand periarticular tissues with the formation of irreversible deformities does not correlate with the HAQ score in patients with RA.