The effect of a lifestyle intervention on metabolic health in young women

• Main Authors: Dunn SL, Siu W, Freund J, Boutcher SH
• Format: Article
• Language: English
• Published: Dove Medical Press 2014-09-01
• Series: Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
• Online Access: http://www.dovepress.com/the-effect-of-a-lifestyle-intervention-on-metabolic-health-in-young-wo-peer-reviewed-article-DMSO

Sarah L Dunn,1 Winnie Siu,2 Judith Freund,2,3 Stephen H Boutcher2 1Department of Kinesiology, University of La Verne, CA, USA; 2School of Medical Sciences, Faculty of Medicine, University of New South Wales, NSW, Australia; 3St Vincent's Hospital, NSW, Australia Abstract: With the increasing obesity rates in Western countries, an effective lifestyle intervention for fat reduction and metabolic benefits is needed. High-intensity intermittent exercise (HIIE), Mediterranean eating habits (Mediet), and fish oil (ω-3) consumption positively impact metabolic health and adiposity, although the combined effect has yet to be determined. A 12-week lifestyle intervention on adiposity, insulin resistance, and interleukin-6 (IL-6) levels of young overweight women was administered. Thirty women with a body mass index of 26.6±0.5 kg/m2, blood pressure of 114/66±1.9/1.5 mmHg, and age of 22±0.8 years were randomly assigned to either an intervention group receiving Mediet advice, daily ω-3 supplementation, and HIIE 3 days/week for 12 weeks or a control group. The group receiving Mediet advice, daily ω-3 supplementation, and HIIE experienced a significant reduction in total body fat mass (P<0.001), abdominal adiposity (P<0.05), waist circumference (P<0.001), systolic blood pressure (P<0.05), fasting plasma insulin (P<0.05), IL-6 (P<0.001), and triglycerides (P<0.05). The greatest decreases in fasting plasma insulin (P<0.05) and IL-6 (P<0.001) occurred by week 6 of the intervention. Significant improvements in eating habits (P<0.05) and aerobic fitness (P<0.001) were also found following the intervention. A multifaceted 12-week lifestyle program comprising a Mediet, ω-3 supplementation, and HIIE induced significant improvements in fat loss, aerobic fitness, and insulin and IL-6 levels, positively influencing metabolic health. Keywords: metabolic syndrome, overweight, exercise, diet