DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder

DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a complex disorder that is underpinned by numerous dysregulated biological pathways, including pathways that affect mitochondrial function. Epigenetic mechanisms contribute to this dysregulation and DNA methylation is an important factor in the etiology of ASD. We m...

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Bibliographic Details
Main Authors: Sophia Bam, Erin Buchanan, Caitlyn Mahony, Colleen O’Ryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Autism Spectrum Disorder
methylation
PGC-1α
mtDNA copy number
metabolomics
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.696428/full

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