Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment
Acute myeloid leukemia (AML) cells home to the endosteal region of the bone marrow. They interact with bone marrow stromal components including extracellular matrix proteins, glycosaminoglycans, and stromal cells, by which they derive proliferative and growth inhibitory signals. Furthermore, adhesio...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/856467 |