The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies With Chinese Hamster Ovary Cells

The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies With Chinese Hamster Ovary Cells

Biopharmaceutical production processes strive for the optimization of economic efficiency. Among others, the maximization of volumetric productivity is a key criterion. Typical parameters such as partial pressure of CO2 (pCO2) and pH are known to influence the performance although reasons are not ye...

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Bibliographic Details
Main Authors: Max Becker, Lisa Junghans, Attila Teleki, Jan Bechmann, Ralf Takors
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
CHO
fed-batch
CO2
pH
flux analysis
metabolomics
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00076/full

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