Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators

Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators

Damage to the mucous membrane is a serious issue associated with chemotherapy. Gastrointestinal (GI) toxicity is complex and multistep process and unregulated production of reactive oxygen species (ROS) and inflammatory mediators play vital role in the development of GI toxicity. In the present stud...

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Bibliographic Details
Main Authors: Abdulrahman Khazim Al-Asmari, Abdul Quaiyoom Khan, Amal Mohammad Al-Qasim, Yara Al-Yousef
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Antineoplastic drugs
Intestinal toxicity
Oxidative stress and inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015300159

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