The Role of Single-Cell Technology in the Study and Control of Infectious Diseases
The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links b...
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1440 |
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doaj-9b5eedb882674a7ab93f231941c47ec52020-11-25T03:11:51ZengMDPI AGCells2073-44092020-06-0191440144010.3390/cells9061440The Role of Single-Cell Technology in the Study and Control of Infectious DiseasesWeikang Nicholas Lin0Matthew Zirui Tay1Ri Lu2Yi Liu3Chia-Hung Chen4Lih Feng Cheow5Department of Biomedical Engineering, National University of Singapore, Singapore 119007, SingaporeSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore 138648, SingaporeNUS Graduate School for Integrated Sciences and Engineering, Singapore 119007, SingaporeDepartment of Biomedical Engineering, National University of Singapore, Singapore 119007, SingaporeDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong 999077, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, National University of Singapore, Singapore 119007, SingaporeThe advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host–pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.https://www.mdpi.com/2073-4409/9/6/1440single cellinfectious diseasepathophysiologytherapeuticsdiagnostics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Weikang Nicholas Lin Matthew Zirui Tay Ri Lu Yi Liu Chia-Hung Chen Lih Feng Cheow |
| spellingShingle |
Weikang Nicholas Lin Matthew Zirui Tay Ri Lu Yi Liu Chia-Hung Chen Lih Feng Cheow The Role of Single-Cell Technology in the Study and Control of Infectious Diseases Cells single cell infectious disease pathophysiology therapeutics diagnostics |
| author_facet |
Weikang Nicholas Lin Matthew Zirui Tay Ri Lu Yi Liu Chia-Hung Chen Lih Feng Cheow |
| author_sort |
Weikang Nicholas Lin |
| title |
The Role of Single-Cell Technology in the Study and Control of Infectious Diseases |
| title_short |
The Role of Single-Cell Technology in the Study and Control of Infectious Diseases |
| title_full |
The Role of Single-Cell Technology in the Study and Control of Infectious Diseases |
| title_fullStr |
The Role of Single-Cell Technology in the Study and Control of Infectious Diseases |
| title_full_unstemmed |
The Role of Single-Cell Technology in the Study and Control of Infectious Diseases |
| title_sort |
role of single-cell technology in the study and control of infectious diseases |
| publisher |
MDPI AG |
| series |
Cells |
| issn |
2073-4409 |
| publishDate |
2020-06-01 |
| description |
The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host–pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development. |
| topic |
single cell infectious disease pathophysiology therapeutics diagnostics |
| url |
https://www.mdpi.com/2073-4409/9/6/1440 |
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