Association studies for asthma and atopic diseases: a comprehensive review of the literature
<p>Abstract</p> <p>Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations wer...
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| Format: | Article |
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BMC
2003-12-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/4/1/14 |
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doaj-9b5dc81be98748bbb2afff9935176e612020-11-24T20:48:01ZengBMCRespiratory Research1465-99212003-12-01411410.1186/1465-9921-4-14Association studies for asthma and atopic diseases: a comprehensive review of the literatureNicolae DanHoffjan SabineOber Carole<p>Abstract</p> <p>Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.</p> http://respiratory-research.com/content/4/1/14 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nicolae Dan Hoffjan Sabine Ober Carole |
| spellingShingle |
Nicolae Dan Hoffjan Sabine Ober Carole Association studies for asthma and atopic diseases: a comprehensive review of the literature Respiratory Research |
| author_facet |
Nicolae Dan Hoffjan Sabine Ober Carole |
| author_sort |
Nicolae Dan |
| title |
Association studies for asthma and atopic diseases: a comprehensive review of the literature |
| title_short |
Association studies for asthma and atopic diseases: a comprehensive review of the literature |
| title_full |
Association studies for asthma and atopic diseases: a comprehensive review of the literature |
| title_fullStr |
Association studies for asthma and atopic diseases: a comprehensive review of the literature |
| title_full_unstemmed |
Association studies for asthma and atopic diseases: a comprehensive review of the literature |
| title_sort |
association studies for asthma and atopic diseases: a comprehensive review of the literature |
| publisher |
BMC |
| series |
Respiratory Research |
| issn |
1465-9921 |
| publishDate |
2003-12-01 |
| description |
<p>Abstract</p> <p>Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.</p> |
| url |
http://respiratory-research.com/content/4/1/14 |
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