Serum lactic dehydrogenase isoenzymes and serum hydroxy butyric dehydrogenase in myocardial infarction

• Main Authors: Kanekar D, Sawant P, Taskar Saroj
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1979-01-01
• Series: Journal of Postgraduate Medicine
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1979;volume=25;issue=1;spage=52;epage=56;aulast=Kanekar

Total serum lactate dehydrogenase activity in cases of myocar-dial infarct is difficult to interpret as abnormal values can occur in diseases of liver, kidney and skeletal muscle. The estimation of its isoenzymes is of better diagnostic help because of its tissue specificity. Serum LDH isoenzymes were studied in patients o f myocardial infarction and results are quantitated by densitometry. As LDH₁ represents serum hydroxybutyric dehydrogenase when 2-oxylbutyrate is used as substrate, serum hydroxybutyric dehydro-genase was also estimated in above patients. Greater specificity in diagnosis is achieved with SHBDH because of its myocardial nature and lower incidence of false positive results.