TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE

TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE

The incidence of neuroendocrine tumors has significantly increased over the last years.The purpose of the study was to analyze treatment outcomes in patients with pancreatic endocrine tumors (PETs) with regard to histopathologic diagnosis.Material and Methods. The clinical records of 1077 patients w...

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Main Authors: A. Z. Isyangulova, R. Sh. Khasanov, R. F. Enikeev, M. G. Gordiev
Format: Article
Language:Russian
Published: Tomsk National Research Medical Center of the Russian Academy of Sciences 2019-11-01
Series:Sibirskij Onkologičeskij Žurnal
Subjects:
pancreatic neuroendocrine tumors
carcinoid tumors
differentiation grade
tumor stage
targeted therapy
somatostatin
Online Access:https://www.siboncoj.ru/jour/article/view/1193
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spelling doaj-9b57624ca7dd469d98fd9548cbef2dda2021-07-28T21:02:06ZrusTomsk National Research Medical Center of the Russian Academy of SciencesSibirskij Onkologičeskij Žurnal1814-48612312-31682019-11-01185808510.21294/1814-4861-2019-18-5-80-85676TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADEA. Z. Isyangulova0R. Sh. Khasanov1R. F. Enikeev2M. G. Gordiev3Tatarstan Cancer CenterKazan State Medical Academy – Branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationTatarstan Cancer CenterNational BioServiceThe incidence of neuroendocrine tumors has significantly increased over the last years.The purpose of the study was to analyze treatment outcomes in patients with pancreatic endocrine tumors (PETs) with regard to histopathologic diagnosis.Material and Methods. The clinical records of 1077 patients with pancreatic tumors were retrospectively analyzed. Fifty patients were diagnosed with PET. Treatment outcomes were assessed with regard to tumor differentiation grade, tumor stage, extent of surgery and drug therapy.Results. The most common histological grade was G1. Patients with G1 tumors had the best 1-and 3-year survival rates regardless of tumor stage. Factors influencing prognosis in patients with PETs were: radical surgery, Ki67 expression level, histological grade (G1–3), tumor stage at diagnosis.https://www.siboncoj.ru/jour/article/view/1193pancreatic neuroendocrine tumorscarcinoid tumorsdifferentiation gradetumor stagetargeted therapysomatostatin
collection DOAJ
language Russian
format Article
sources DOAJ
author A. Z. Isyangulova
R. Sh. Khasanov
R. F. Enikeev
M. G. Gordiev
spellingShingle A. Z. Isyangulova
R. Sh. Khasanov
R. F. Enikeev
M. G. Gordiev
TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
Sibirskij Onkologičeskij Žurnal
pancreatic neuroendocrine tumors
carcinoid tumors
differentiation grade
tumor stage
targeted therapy
somatostatin
author_facet A. Z. Isyangulova
R. Sh. Khasanov
R. F. Enikeev
M. G. Gordiev
author_sort A. Z. Isyangulova
title TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
title_short TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
title_full TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
title_fullStr TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
title_full_unstemmed TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
title_sort treatment of patients with pancreatic neuroendocrine tumours depending on the differentiation grade
publisher Tomsk National Research Medical Center of the Russian Academy of Sciences
series Sibirskij Onkologičeskij Žurnal
issn 1814-4861
2312-3168
publishDate 2019-11-01
description The incidence of neuroendocrine tumors has significantly increased over the last years.The purpose of the study was to analyze treatment outcomes in patients with pancreatic endocrine tumors (PETs) with regard to histopathologic diagnosis.Material and Methods. The clinical records of 1077 patients with pancreatic tumors were retrospectively analyzed. Fifty patients were diagnosed with PET. Treatment outcomes were assessed with regard to tumor differentiation grade, tumor stage, extent of surgery and drug therapy.Results. The most common histological grade was G1. Patients with G1 tumors had the best 1-and 3-year survival rates regardless of tumor stage. Factors influencing prognosis in patients with PETs were: radical surgery, Ki67 expression level, histological grade (G1–3), tumor stage at diagnosis.
topic pancreatic neuroendocrine tumors
carcinoid tumors
differentiation grade
tumor stage
targeted therapy
somatostatin
url https://www.siboncoj.ru/jour/article/view/1193
work_keys_str_mv AT azisyangulova treatmentofpatientswithpancreaticneuroendocrinetumoursdependingonthedifferentiationgrade
AT rshkhasanov treatmentofpatientswithpancreaticneuroendocrinetumoursdependingonthedifferentiationgrade
AT rfenikeev treatmentofpatientswithpancreaticneuroendocrinetumoursdependingonthedifferentiationgrade
AT mggordiev treatmentofpatientswithpancreaticneuroendocrinetumoursdependingonthedifferentiationgrade
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