Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.

Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.

SynGAP, a protein abundant at the postsynaptic density (PSD) of glutamatergic neurons, is known to modulate synaptic strength by regulating the incorporation of AMPA receptors at the synapse. Two isoforms of SynGAP, α1 and α2, which differ in their C-termini, have opposing effects on synaptic streng...

Full description

Bibliographic Details
Main Authors: Yijung Yang, Jung-Hwa Tao-Cheng, K Ulrich Bayer, Thomas S Reese, Ayse Dosemeci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742523?pdf=render

Internet

http://europepmc.org/articles/PMC3742523?pdf=render

Similar Items