IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes

IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes

Autoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflam...

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Bibliographic Details
Main Authors: Chittappen K. Prajeeth, Oliver Dittrich-Breiholz, Steven R. Talbot, Philippe A. Robert, Jochen Huehn, Martin Stangel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microglia
astrocytes
Th1 cells
cytokines
interferon-γ
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00352/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00352/full

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