Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

<p>Abstract</p> <p>Background</p> <p>Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown t...

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Bibliographic Details
Main Authors: Byler Timothy K, Leocadio Dean, Shapiro Oleg, Bratslavsky Gennady, Stodgell Christopher J, Wood Ronald W, Messing Edward M, Reeder Jay E
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Urology
Subjects:
Bladder cancer
Valproic acid
Thrombospondin-1, Urothelial carcinoma
Gene expression
Online Access:http://www.biomedcentral.com/1471-2490/12/21

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