Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage

Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage

Abstract Our previous studies demonstrated that vitamin A deficiency (VAD) can impair the postnatal cognitive function of rats by damaging the hippocampus. The present study examined the effects of retinoic acid (RA) on apoptosis induced by hypoxic-ischemic damage in vivo and in vitro, and investiga...

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Bibliographic Details
Main Authors: Wei Jiang, Min Guo, Min Gong, Li Chen, Yang Bi, Yun Zhang, Yuan Shi, Ping Qu, Youxue Liu, Jie Chen, Tingyu Li
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Brain
Subjects:
Vitamin A (VA)
Hypoxic-ischemic brain damage (HIBD)
Retinoic acid (RA)
Apoptosis
Mitochondrial membrane potential (MMP)
PI3K/Akt
Online Access:http://link.springer.com/article/10.1186/s13041-018-0360-0

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