Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors

Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors

Pyrazoles are potent medicinal scaffolds and exhibit a wide spectrum of biological activities, such as analgesic, anti-inflammatory and antipyretic. In this paper we report on research we have performed with the aim of continuing the biological evaluation of the regio-isomeric pyrazole compounds, LQ...

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Bibliographic Details
Main Authors: Iziara F. Florentino, Daiany P.B. Silva, Carina Sofia Cardoso, Ricardo Menegatti, Flávio S. de Carvalho, Luciano M. Lião, Paulo M. Pinto, Steve Peigneur, Elson A. Costa, Jan Tytgat
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Analgesic
Electrophysiology
Ion channels
Pain
Pyrazole compounds
Receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218376352

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