Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study
It is a clinical challenge to obtain a sufficient orthopaedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. Bisphosphonate can be used to prevent the o...
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| Format: | Article |
| Language: | English |
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AO Research Institute Davos
2008-07-01
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| Series: | European Cells & Materials |
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| Online Access: | http://www.ecmjournal.org/journal/papers/vol016/pdf/v016a02.pdf |