Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors

Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors

Abstract Background Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the interstitial fluid pressure (PIF) in most solid tumors. An increased t...

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Bibliographic Details
Main Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed, Linda Stuhr
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Integrin α11β1
Interstitial fluid pressure
Cancer associated fibroblasts
Collagen organization
Triple-negative breast cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-5449-z

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http://link.springer.com/article/10.1186/s12885-019-5449-z

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