Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

Nobiletin, a major component of citrus fruits, is a polymethoxyflavone derivative that exhibits anticancer activity against several forms of cancer, including SNU-16 human gastric cancer cells. To explore the nobiletin-induced cell death mechanism, we examined the changes in protein expression cause...

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Bibliographic Details
Main Authors: Jeong Yong Moon, Somi Kim Cho
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
apoptosis
autophagy
ER stress
GRP78
nobiletin
SNU-16
Online Access:http://www.mdpi.com/1420-3049/21/7/914

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