Alzheimer’s Disease: A Thermodynamic Perspective

Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 co...

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Main Authors:	Umberto Lucia, Giulia Grisolia, Thomas S. Deisboeck
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Applied Sciences
Subjects:	Alzheimer irreversible thermodyamics ion fluxes thermodynamic approach to biosystems transport processes
Online Access:	https://www.mdpi.com/2076-3417/10/21/7562

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spelling	doaj-9b12fc3212844dd9ae98105529ca0eed2020-11-25T03:36:28ZengMDPI AGApplied Sciences2076-34172020-10-01107562756210.3390/app10217562Alzheimer’s Disease: A Thermodynamic PerspectiveUmberto Lucia0Giulia Grisolia1Thomas S. Deisboeck2Dipartimento Energia “Galileo Ferraris”, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, ItalyDipartimento Energia “Galileo Ferraris”, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, ItalyDepartment of Radiology, Harvard-MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USAAlzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula>/K<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula> currents which in turn impacts synaptic transmission and reduces plasticity.https://www.mdpi.com/2076-3417/10/21/7562Alzheimerirreversible thermodyamicsion fluxesthermodynamic approach to biosystemstransport processes
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Umberto Lucia Giulia Grisolia Thomas S. Deisboeck
spellingShingle	Umberto Lucia Giulia Grisolia Thomas S. Deisboeck Alzheimer’s Disease: A Thermodynamic Perspective Applied Sciences Alzheimer irreversible thermodyamics ion fluxes thermodynamic approach to biosystems transport processes
author_facet	Umberto Lucia Giulia Grisolia Thomas S. Deisboeck
author_sort	Umberto Lucia
title	Alzheimer’s Disease: A Thermodynamic Perspective
title_short	Alzheimer’s Disease: A Thermodynamic Perspective
title_full	Alzheimer’s Disease: A Thermodynamic Perspective
title_fullStr	Alzheimer’s Disease: A Thermodynamic Perspective
title_full_unstemmed	Alzheimer’s Disease: A Thermodynamic Perspective
title_sort	alzheimer’s disease: a thermodynamic perspective
publisher	MDPI AG
series	Applied Sciences
issn	2076-3417
publishDate	2020-10-01
description	Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula>/K<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula> currents which in turn impacts synaptic transmission and reduces plasticity.
topic	Alzheimer irreversible thermodyamics ion fluxes thermodynamic approach to biosystems transport processes
url	https://www.mdpi.com/2076-3417/10/21/7562
work_keys_str_mv	AT umbertolucia alzheimersdiseaseathermodynamicperspective AT giuliagrisolia alzheimersdiseaseathermodynamicperspective AT thomassdeisboeck alzheimersdiseaseathermodynamicperspective
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Alzheimer’s Disease: A Thermodynamic Perspective

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