Alzheimer’s Disease: A Thermodynamic Perspective

Alzheimer’s Disease: A Thermodynamic Perspective

Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 co...

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Bibliographic Details
Main Authors: Umberto Lucia, Giulia Grisolia, Thomas S. Deisboeck
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Applied Sciences
Subjects:
Alzheimer
irreversible thermodyamics
ion fluxes
thermodynamic approach to biosystems
transport processes
Online Access:https://www.mdpi.com/2076-3417/10/21/7562
Description
Summary:Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula>/K<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>+</mo></msup></semantics></math></inline-formula> currents which in turn impacts synaptic transmission and reduces plasticity.
ISSN:2076-3417

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