Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms

Respiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the dos...

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Main Authors: James T. Van Leuven, Andres J. Gonzalez, Emmanuel C. Ijezie, Alexander Q. Wixom, John L. Clary, Maricris N. Naranjo, Benjamin J. Ridenhour, Craig R. Miller, Tanya A. Miura
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00479-21
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spelling doaj-9b12696f76094b6c8c8fdb1b37cf12082021-09-21T20:35:24ZengAmerican Society for MicrobiologymSphere2379-50422021-06-016310.1128/mSphere.00479-21Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent MechanismsJames T. Van Leuven0Andres J. Gonzalez1Emmanuel C. Ijezie2Alexander Q. Wixom3John L. Clary4Maricris N. Naranjo5Benjamin J. Ridenhour6Craig R. Miller7Tanya A. Miura8Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USADepartment of Plant Sciences, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USADepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USA Respiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the doses, timing, and strains of coinfecting viruses are critical to understanding how coinfection affects disease severity.https://journals.asm.org/doi/10.1128/mSphere.00479-21
collection DOAJ
language English
format Article
sources DOAJ
author James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
spellingShingle James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
mSphere
author_facet James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
author_sort James T. Van Leuven
title Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_short Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_full Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_fullStr Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_full_unstemmed Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_sort rhinovirus reduces the severity of subsequent respiratory viral infections by interferon-dependent and -independent mechanisms
publisher American Society for Microbiology
series mSphere
issn 2379-5042
publishDate 2021-06-01
description Respiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the doses, timing, and strains of coinfecting viruses are critical to understanding how coinfection affects disease severity.
url https://journals.asm.org/doi/10.1128/mSphere.00479-21
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