Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen
Therapeutic cancer vaccines have the potential to generate a long lasting immune response that will destroy tumor cells with specificity and safety, in contrast to many other current cancer therapies. Clinical success to date has been limited by a number of factors including choice of immunogenic ca...
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MDPI AG
2011-10-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/3/4/3991/ |
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doaj-9b0834ded63e41fabcbc09ffbb595c042020-11-25T00:03:04ZengMDPI AGCancers2072-66942011-10-01343991400910.3390/cancers3043991Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory RegimenJames E. EganPaul H. NaylorNeil L. BerinsteinTherapeutic cancer vaccines have the potential to generate a long lasting immune response that will destroy tumor cells with specificity and safety, in contrast to many other current cancer therapies. Clinical success to date has been limited by a number of factors including choice of immunogenic cancer rejection antigens, optimization of vaccine platforms and immune adjuvants to effectively polarize the immune response, and incorporation of strategies to reverse cancer mediated immune suppression by utilization of effective adjuvant/immune modulators. WT-1 (Wilms’ tumor gene 1) is a cancer antigen that is required for tumorigenesis, expressed in a high percentage of tumor cells and rarely expressed in adult normal cells. Moreover spontaneous immunity to WT-1 is seen in cancer patients and can be augmented with various therapeutic vaccine approaches. IRX-2 is an immune modulator with demonstrated preclinical and clinical pleiotropic immune activities including enhancement of the immune response to potential tumor antigens. This paper presents the rationale and preclinical data for utilizing the WT-1 tumor antigen in a novel vaccine platform consisting of a synthetic long peptide containing multiple class I and class II epitopes in combination with the IRX-2 immunomodulatory regimen to overcome immuno-suppressive pathways and enhance the anti-tumor response.http://www.mdpi.com/2072-6694/3/4/3991/IRX-2synthetic long peptidesWilms’ tumor gene 1WT-1cancer vaccineimmunomodulatoradjuvant |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
James E. Egan Paul H. Naylor Neil L. Berinstein |
| spellingShingle |
James E. Egan Paul H. Naylor Neil L. Berinstein Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen Cancers IRX-2 synthetic long peptides Wilms’ tumor gene 1 WT-1 cancer vaccine immunomodulator adjuvant |
| author_facet |
James E. Egan Paul H. Naylor Neil L. Berinstein |
| author_sort |
James E. Egan |
| title |
Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen |
| title_short |
Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen |
| title_full |
Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen |
| title_fullStr |
Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen |
| title_full_unstemmed |
Peptide Based Vaccine Approaches for Cancer—A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen |
| title_sort |
peptide based vaccine approaches for cancer—a novel approach using a wt-1 synthetic long peptide and the irx-2 immunomodulatory regimen |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2011-10-01 |
| description |
Therapeutic cancer vaccines have the potential to generate a long lasting immune response that will destroy tumor cells with specificity and safety, in contrast to many other current cancer therapies. Clinical success to date has been limited by a number of factors including choice of immunogenic cancer rejection antigens, optimization of vaccine platforms and immune adjuvants to effectively polarize the immune response, and incorporation of strategies to reverse cancer mediated immune suppression by utilization of effective adjuvant/immune modulators. WT-1 (Wilms’ tumor gene 1) is a cancer antigen that is required for tumorigenesis, expressed in a high percentage of tumor cells and rarely expressed in adult normal cells. Moreover spontaneous immunity to WT-1 is seen in cancer patients and can be augmented with various therapeutic vaccine approaches. IRX-2 is an immune modulator with demonstrated preclinical and clinical pleiotropic immune activities including enhancement of the immune response to potential tumor antigens. This paper presents the rationale and preclinical data for utilizing the WT-1 tumor antigen in a novel vaccine platform consisting of a synthetic long peptide containing multiple class I and class II epitopes in combination with the IRX-2 immunomodulatory regimen to overcome immuno-suppressive pathways and enhance the anti-tumor response. |
| topic |
IRX-2 synthetic long peptides Wilms’ tumor gene 1 WT-1 cancer vaccine immunomodulator adjuvant |
| url |
http://www.mdpi.com/2072-6694/3/4/3991/ |
| work_keys_str_mv |
AT jameseegan peptidebasedvaccineapproachesforcanceranovelapproachusingawt1syntheticlongpeptideandtheirx2immunomodulatoryregimen AT paulhnaylor peptidebasedvaccineapproachesforcanceranovelapproachusingawt1syntheticlongpeptideandtheirx2immunomodulatoryregimen AT neillberinstein peptidebasedvaccineapproachesforcanceranovelapproachusingawt1syntheticlongpeptideandtheirx2immunomodulatoryregimen |
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