Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease

Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease

Alzheimer's disease (AD) is a fast growing neurodegenerative disorder of the central nervous system and anti-oxidants can be used to help suppress the oxidative stress caused by the free radicals that are responsible for AD. A series of selected synthetic indole derivatives were biologically ev...

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Bibliographic Details
Main Authors: Muhammad Yar, Muhammad Arshad, Ariba Farooq, Mazhar Amjad Gilani, Khurshid Ayub, Asma Ejaz, Anupriya Kumar, Ichiya Ninomiya
Format: Article
Language:English
Published: Universidade de São Paulo 2015-03-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Doença de Alzheimer
Compostos antioxidantes
Doenças crônicas
Teoria do Funcional de Densidade
Ancoramento molecular
Estudos computacionais
Ensaio de DPPH
Derivados do indol
Acetilcolinesterase (AChE)
Butirilcolinesterase (BChE)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100053&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100053&lng=en&tlng=en

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