Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Abstract Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle‐cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR‐mediat...

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Bibliographic Details
Main Authors: Joseph Hawksworth, Timothy J Satchwell, Marjolein Meinders, Deborah E Daniels, Fiona Regan, Nicole M Thornton, Marieangela C Wilson, Johannes GG Dobbe, Geert J Streekstra, Kongtana Trakarnsanga, Kate J Heesom, David J Anstee, Jan Frayne, Ashley M Toye
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:EMBO Molecular Medicine
Subjects:
BEL‐A
CRISPR
erythroid
transfusion
universal donor
Online Access:https://doi.org/10.15252/emmm.201708454

Internet

https://doi.org/10.15252/emmm.201708454

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