Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network

Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network

Here, the authors apply genetic fate mapping and temporal clonal analysis to study progenitor recruitment and network morphogenesis of murine cardiac Purkinje fibers. Additionally, they characterize how transcription factor dosage regulates cell fate divergence during distinct phases of this process...

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Bibliographic Details
Main Authors: Caroline Choquet, Robert G. Kelly, Lucile Miquerol
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19150-9
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spelling doaj-9af35e55e4eb4b408bf69b7f0c73faf62021-05-11T08:05:15ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-19150-9Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber networkCaroline Choquet0Robert G. Kelly1Lucile Miquerol2Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of MarseilleAix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of MarseilleAix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of MarseilleHere, the authors apply genetic fate mapping and temporal clonal analysis to study progenitor recruitment and network morphogenesis of murine cardiac Purkinje fibers. Additionally, they characterize how transcription factor dosage regulates cell fate divergence during distinct phases of this process.https://doi.org/10.1038/s41467-020-19150-9
collection DOAJ
language English
format Article
sources DOAJ
author Caroline Choquet
Robert G. Kelly
Lucile Miquerol
spellingShingle Caroline Choquet
Robert G. Kelly
Lucile Miquerol
Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
Nature Communications
author_facet Caroline Choquet
Robert G. Kelly
Lucile Miquerol
author_sort Caroline Choquet
title Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
title_short Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
title_full Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
title_fullStr Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
title_full_unstemmed Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network
title_sort nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac purkinje fiber network
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Here, the authors apply genetic fate mapping and temporal clonal analysis to study progenitor recruitment and network morphogenesis of murine cardiac Purkinje fibers. Additionally, they characterize how transcription factor dosage regulates cell fate divergence during distinct phases of this process.
url https://doi.org/10.1038/s41467-020-19150-9
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AT robertgkelly nkx25definesdistinctscaffoldandrecruitmentphasesduringformationofthemurinecardiacpurkinjefibernetwork
AT lucilemiquerol nkx25definesdistinctscaffoldandrecruitmentphasesduringformationofthemurinecardiacpurkinjefibernetwork
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