Ranolazine preserves and improves left ventricular ejection fraction and autonomic measures when added to guideline-driven therapy in chronic heart failure

Ranolazine preserves and improves left ventricular ejection fraction and autonomic measures when added to guideline-driven therapy in chronic heart failure

Background Ranolazine (RAN) reduces cardiac sodium channel 1.5’s late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympat...

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Bibliographic Details
Main Authors: Murray, Gary, Colombo, Joseph
Format: Article
Language:English
Published: Touch Medical Media 2014-12-01
Series:Heart International
Subjects:
Congestive heart failure
Left ventricular ejection fraction
Parasympathetic function
Patient outcomes
Ranolazine
Sympathetic function
Online Access:http://www.heart-int.com/article/ranolazine-preserves-and-improves-left-ventricular-ejection-fraction-and-autonomic-measures-when-added-to-guideline-driven-therapy-in-chronic-heart-fa

Internet

http://www.heart-int.com/article/ranolazine-preserves-and-improves-left-ventricular-ejection-fraction-and-autonomic-measures-when-added-to-guideline-driven-therapy-in-chronic-heart-fa

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