High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
Abstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
|
Series: | Cardiovascular Diabetology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12933-021-01310-w |
id |
doaj-9ae80199f4f64da7871413fea4e01282 |
---|---|
record_format |
Article |
spelling |
doaj-9ae80199f4f64da7871413fea4e012822021-06-13T11:32:23ZengBMCCardiovascular Diabetology1475-28402021-06-0120111210.1186/s12933-021-01310-wHigh plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgeryLucia La Sala0Elena Tagliabue1Elaine Vieira2Antonio E Pontiroli3Franco Folli4Lab. of Cardiovascular and Dysmetabolic Disease, IRCCS MultiMedicaValue-based Healthcare Unit, IRCCS MultiMedicaPostgraduate Program on Physical Education, Universidade Católica de BrasíliaDipartimento di Scienze della Salute, Università degli Studi di MilanoDipartimento di Scienze della Salute, Università degli Studi di MilanoAbstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance. Methods 239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)]. Results At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB. Conclusions These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.https://doi.org/10.1186/s12933-021-01310-wReninAldosteroneDiabetesHOMA indexHypertensionObesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia La Sala Elena Tagliabue Elaine Vieira Antonio E Pontiroli Franco Folli |
spellingShingle |
Lucia La Sala Elena Tagliabue Elaine Vieira Antonio E Pontiroli Franco Folli High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery Cardiovascular Diabetology Renin Aldosterone Diabetes HOMA index Hypertension Obesity |
author_facet |
Lucia La Sala Elena Tagliabue Elaine Vieira Antonio E Pontiroli Franco Folli |
author_sort |
Lucia La Sala |
title |
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
title_short |
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
title_full |
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
title_fullStr |
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
title_full_unstemmed |
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
title_sort |
high plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2021-06-01 |
description |
Abstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance. Methods 239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)]. Results At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB. Conclusions These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism. |
topic |
Renin Aldosterone Diabetes HOMA index Hypertension Obesity |
url |
https://doi.org/10.1186/s12933-021-01310-w |
work_keys_str_mv |
AT lucialasala highplasmareninactivityassociateswithobesityrelateddiabetesandarterialhypertensionandpredictspersistenthypertensionafterbariatricsurgery AT elenatagliabue highplasmareninactivityassociateswithobesityrelateddiabetesandarterialhypertensionandpredictspersistenthypertensionafterbariatricsurgery AT elainevieira highplasmareninactivityassociateswithobesityrelateddiabetesandarterialhypertensionandpredictspersistenthypertensionafterbariatricsurgery AT antonioepontiroli highplasmareninactivityassociateswithobesityrelateddiabetesandarterialhypertensionandpredictspersistenthypertensionafterbariatricsurgery AT francofolli highplasmareninactivityassociateswithobesityrelateddiabetesandarterialhypertensionandpredictspersistenthypertensionafterbariatricsurgery |
_version_ |
1721379707981660160 |