High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery

Abstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference...

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Main Authors: Lucia La Sala, Elena Tagliabue, Elaine Vieira, Antonio E Pontiroli, Franco Folli
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cardiovascular Diabetology
Subjects:
Online Access:https://doi.org/10.1186/s12933-021-01310-w
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spelling doaj-9ae80199f4f64da7871413fea4e012822021-06-13T11:32:23ZengBMCCardiovascular Diabetology1475-28402021-06-0120111210.1186/s12933-021-01310-wHigh plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgeryLucia La Sala0Elena Tagliabue1Elaine Vieira2Antonio E Pontiroli3Franco Folli4Lab. of Cardiovascular and Dysmetabolic Disease, IRCCS MultiMedicaValue-based Healthcare Unit, IRCCS MultiMedicaPostgraduate Program on Physical Education, Universidade Católica de BrasíliaDipartimento di Scienze della Salute, Università degli Studi di MilanoDipartimento di Scienze della Salute, Università degli Studi di MilanoAbstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance. Methods 239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)]. Results At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB. Conclusions These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.https://doi.org/10.1186/s12933-021-01310-wReninAldosteroneDiabetesHOMA indexHypertensionObesity
collection DOAJ
language English
format Article
sources DOAJ
author Lucia La Sala
Elena Tagliabue
Elaine Vieira
Antonio E Pontiroli
Franco Folli
spellingShingle Lucia La Sala
Elena Tagliabue
Elaine Vieira
Antonio E Pontiroli
Franco Folli
High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
Cardiovascular Diabetology
Renin
Aldosterone
Diabetes
HOMA index
Hypertension
Obesity
author_facet Lucia La Sala
Elena Tagliabue
Elaine Vieira
Antonio E Pontiroli
Franco Folli
author_sort Lucia La Sala
title High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
title_short High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
title_full High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
title_fullStr High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
title_full_unstemmed High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
title_sort high plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
publisher BMC
series Cardiovascular Diabetology
issn 1475-2840
publishDate 2021-06-01
description Abstract Background Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance. Methods 239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)]. Results At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB. Conclusions These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.
topic Renin
Aldosterone
Diabetes
HOMA index
Hypertension
Obesity
url https://doi.org/10.1186/s12933-021-01310-w
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