The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

Objective: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether lepti...

Full description

Bibliographic Details
Main Authors:	Heather C. Denroche, Michelle M. Kwon, Maria M. Glavas, Eva Tudurí, Marion Philippe, Whitney L. Quong, Timothy J. Kieffer
Format:	Article
Language:	English
Published:	Elsevier 2016-08-01
Series:	Molecular Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877816300722

Similar Items

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
by: Michelle M. Kwon, et al.
Published: (2015-11-01)

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.
by: Eva Tudurí, et al.
Published: (2013-01-01)

The glucoregulatory actions of leptin
by: Anna M. D'souza, et al.
Published: (2017-09-01)

The metabolic effects of leptin therapy in a mouse model of type 1 diabetes.
by: Denroche, Heather Courtney
Published: (2014)

The metabolic effects of leptin therapy in a mouse model of type 1 diabetes.
by: Denroche, Heather Courtney
Published: (2014)

Role of myeloid cell leptin signaling in the regulation of glucose metabolism
by: Sandra Pereira, et al.
Published: (2021-09-01)

The effects of gastric and homeostatic autonomic afferent reflexes on cardiac autonomic efferent activity in healthy human volunteers
by: Kazadi, Lubobo-Claude
Published: (2015)

The claustrum of the ferret: afferent and efferent connections to lower and higher order visual cortical areas.
by: Nina ePatzke, et al.
Published: (2014-02-01)

Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae
by: Kulika Chomvong, et al.
Published: (2017-08-01)

Efferent Treatment for Critical Conditions
by: S. E. Khoroshilov, et al.
Published: (2012-08-01)

Application of High Frequency Electrical Block on the Efferent Nerves to the Lower Urinary Tract for Bladder Voiding
by: Boger, Adam Sprott
Published: (2009)

Efferent Control of the Human Auditory System
by: Garinis, Angela
Published: (2008)

GABA, substance P and the efferents of the striatum
by: Vincent, Steven Robert
Published: (2010)

Efferent and other effects on arterial chemoreceptors
by: Goodman, N. W.
Published: (1974)

Reflex activation of vagal efferent neurones
by: Jewett, D. L.
Published: (1963)

The role of efference copy in striatal learning
by: Fee, Michale S.
Published: (2016)

Neurophysiological evidence of efference copies to inner speech
by: Thomas J Whitford, et al.
Published: (2017-12-01)

Walking speed and brain glucose uptake are uncoupled in patients with multiple sclerosis
by: John H. Kindred, et al.
Published: (2015-02-01)

The role of leptin in the regulation of glucose homeostasis
by: Levi, Jasna
Published: (2010)

Effects of glucose and leptin on folliculogenesis of the ewe
by: Munoz-Gutierrez, Minerva
Published: (2006)

The role of leptin in the regulation of glucose homeostasis
by: Levi, Jasna
Published: (2010)

The role of leptin in the regulation of glucose homeostasis
by: Levi, Jasna
Published: (2010)

Afferent vs. efferent cervical vagal nerve stimulation: effects on blood glucose, insulin, and glucagon concentrations in rats
by: Meyers, Erin Elizabeth
Published: (2016)

Efferent inhibition of otoacoustic emissions in preterm neonates
by: Renata Mota Mamede Carvallo, et al.
Published: (2015-10-01)

Periaqueductal efferents to dopamine and GABA neurons of the VTA.
by: Niels R Ntamati, et al.
Published: (2018-01-01)

Contralateral efferent suppression of human hearing sensitivity
by: Enzo eAguilar, et al.
Published: (2015-01-01)

The early development of the tectal efferent projection in the chick
by: Shepherd, Iain Thomas
Published: (1994)

Auditory Processing and the Medial Olivocochlear Efferent System
by: Ferry, Robert Thomas
Published: (2008)

The influence of efferent fibres on lateral-line organs
by: Russell, I. J.
Published: (1969)

Browning of white adipose tissue uncouples glucose uptake from insulin signaling.
by: Karin Mössenböck, et al.
Published: (2014-01-01)

Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis.
by: Guoyan Liang, et al.
Published: (2012-01-01)

Interaction of glucose sensing and leptin action in the brain
by: Rosa J.W. Li, et al.
Published: (2020-09-01)

The role of leptin in the control of insulin-glucose axis
by: Marie eAmitani, et al.
Published: (2013-04-01)

Leptin therapy, insulin sensitivity, and glucose homeostasis
by: Gilberto Paz-Filho, et al.
Published: (2012-01-01)

Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma
by: Daniel T. Hass, et al.
Published: (2019-03-01)

Central leptin and autonomic regulation: A melanocortin business
by: Miguel López
Published: (2018-02-01)

Some efferent neocortical projections in the armadillo Dasypus novemcinctus /
by: Harting, John Kelly
Published: (1969)

Efferent auditory system: its effect on auditory processing
by: Fernanda Acaui Ribeiro Burguetti, et al.
Published: (2008-09-01)

Medial efferent mechanisms in children with auditory processing disorders
by: Srikanta eMishra
Published: (2014-10-01)

Extra-Adrenal Myelolipoma Presenting as Efferent Limb Obstruction
by: Alexandria Conley, et al.
Published: (2012-01-01)