Role of p97/VCP (Cdc48) in genome stability

Role of p97/VCP (Cdc48) in genome stability

Ubiquitin-dependent molecular chaperone p97, also known as valosin-containing protein (VCP) or Cdc48, is an AAA ATPase involved in protein turnover and degradation. p97 converts its own ATPase hydrolysis into remodelling activity on a myriad of ubiquitinated substrates from different cellular locati...

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Bibliographic Details
Main Authors: Bruno eVaz, Swagata eHalder, Kristijan eRamadan
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Genetics
Subjects:
DNA Repair
DNA Replication
DNA damage response
genome stability
p97/VCP
Cdc48
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00060/full

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