Change of left ventricular ultrasonic functional parameters in patients with ACS during peri-PCI period and their relationship with degree of serum myocardial damage

• Main Author: Yan Yan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Acute coronary syndrome Percutaneous coronary intervention Left ventricular ultrasonic functional parameters Myocardial injury
• Online Access: http://www.hnykdxxb.com/PDF/201711/19.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the change of left ventricular ultrasonic functional parameters in patients with ACS during peri-PCI period and their relationship with degree of serum myocardial damage. Methods: A total of 76 cases of ACS patients who were treated in our hospital between June 2012 and January 2016 were selected as research subjects, treatment methods were reviewed and then all patients were divided into observation group (n＝57) who underwent PCI treatment and control group (n＝19) who conformed to PCI indications but underwent conservative treatment under patients’ or families’ insistence. Left ventricular ultrasonic functional parameter levels and serum myocardial injury index contents were compared between two groups of patients before and after treatment. Pearson test was used to evaluate the relationship between left ventricular ultrasonic functional parameters and myocardial injury in patients with ACS. Results: Before treatment, differences in left ventricular ultrasonic functional parameter levels as well as serum contents of myocardial enzyme spectrum and myocardial apoptosis indexes were not statistically significant between the two groups of patients. After treatment, left ventricular ultrasonic functional parameters LVEDD and LVESD levels in observation group were lower than those in control group while SV level was higher than that in control group; serum contents of myocardial enzyme spectrum cTnT, LDH, CK-MB and AST were lower than those in control group; serum contents of myocardial apoptosis indexes Fas, Caspase-3 and caspase-12 were lower than those in control group while Bcl-2 content was higher than that in control group. The left ventricular ultrasonic functional parameters in ACS patients were directly correlated with the degree of myocardial injury. Conclusion: PCI treatment of patients with ACS can significantly improve left ventricular function and reduce myocardial injury. After treatment, the left ventricular ultrasonic functional parameters are directly correlated with the degree of myocardial injury.