Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of vessels including possibly that of brain tumors....

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Bibliographic Details
Main Authors: Jérôme Côté, Veronica Bovenzi, Martin Savard, Céléna Dubuc, Audrey Fortier, Witold Neugebauer, Luc Tremblay, Werner Müller-Esterl, Ana-Maria Tsanaclis, Martin Lepage, David Fortin, Fernand Gobeil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3357387?pdf=render

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http://europepmc.org/articles/PMC3357387?pdf=render

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