Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states tha...

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Main Authors:	Yehuda Schlesinger, Oshri Yosefov-Levi, Dror Kolodkin-Gal, Roy Zvi Granit, Luriano Peters, Rachel Kalifa, Lei Xia, Abdelmajeed Nasereddin, Idit Shiff, Osher Amran, Yuval Nevo, Sharona Elgavish, Karine Atlan, Gideon Zamir, Oren Parnas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18207-z

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spelling	doaj-9ac32cd2b6ea40c9ae2b5bb608e74f222021-09-12T11:48:13ZengNature Publishing GroupNature Communications2041-17232020-09-0111111810.1038/s41467-020-18207-zSingle-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneityYehuda Schlesinger0Oshri Yosefov-Levi1Dror Kolodkin-Gal2Roy Zvi Granit3Luriano Peters4Rachel Kalifa5Lei Xia6Abdelmajeed Nasereddin7Idit Shiff8Osher Amran9Yuval Nevo10Sharona Elgavish11Karine Atlan12Gideon Zamir13Oren Parnas14The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolDepartment of Surgery, Hadassah–Hebrew University Medical CenterThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolDepartment of Surgery, Hadassah–Hebrew University Medical CenterThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolGenomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of JerusalemGenomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of JerusalemThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolInfo-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical CenterInfo-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical CenterDepartment of Pathology, Hadassah–Hebrew University Medical CenterDepartment of Surgery, Hadassah–Hebrew University Medical CenterThe Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University–Hadassah Medical SchoolPancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states that are heterogeneous and have unique transcription programs.https://doi.org/10.1038/s41467-020-18207-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas
spellingShingle	Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity Nature Communications
author_facet	Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas
author_sort	Yehuda Schlesinger
title	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_short	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_full	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_fullStr	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_full_unstemmed	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_sort	single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states that are heterogeneous and have unique transcription programs.
url	https://doi.org/10.1038/s41467-020-18207-z
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Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

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