The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

• Main Authors: Sandeep Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2011-01-01
• Series: Journal of Advanced Pharmaceutical Technology & Research
• Subjects: Diabetes; dyslipidemia; peroxisome proliferator-activated receptors
• Online Access: http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=4;spage=236;epage=240;aulast=Tyagi

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR- β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function. The present review critically analyzes the protective and detrimental effect of PPAR agonists in dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity.