A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice

The protracted and age-dependent degeneration of dopamine (DA)-producing neurons of the Substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in the mammalian midbrain is a hallmark of human Parkinson's Disease (PD) and of certain genetic mouse models of PD, such as mice heteroz...

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Bibliographic Details
Main Authors: Jingzhong Zhang, Sebastian Götz, Daniela M. Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst, Nilima Prakash
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Dopamine neuron
Parkinson's Disease
Neuroprotection
Survival
Lef1
Lmx1a
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001898

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