Immunoadsorption for Treatment of Patients with Suspected Alzheimer Dementia and Agonistic Autoantibodies against Alpha1a-Adrenoceptor—Rationale and Design of the IMAD Pilot Study

Immunoadsorption for Treatment of Patients with Suspected Alzheimer Dementia and Agonistic Autoantibodies against Alpha1a-Adrenoceptor—Rationale and Design of the IMAD Pilot Study

Background: agonistic autoantibodies (agAABs) against G protein-coupled receptors (GPCR) have been linked to cardiovascular disease. In dementia patients, GPCR-agAABs against the α1- and ß2-adrenoceptors (α1AR- and ß2AR) were found at a prevalence of 50%. Elimination of agAABs by immunoadsorption (I...

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Bibliographic Details
Main Authors: Sylvia Stracke, Sandra Lange, Sarah Bornmann, Holger Kock, Lara Schulze, Johanna Klinger-König, Susanne Böhm, Antje Vogelgesang, Felix von Podewils, Agnes Föel, Stefan Gross, Katrin Wenzel, Gerd Wallukat, Harald Prüss, Alexander Dressel, Rudolf Kunze, Hans J. Grabe, Sönke Langner, Marcus Dörr
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Journal of Clinical Medicine
Subjects:
Alzheimer’s clinical syndrome
dementia
immunoadsorption
autoantibodies
α1-Adrenergic receptor
Online Access:https://www.mdpi.com/2077-0383/9/6/1919

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