Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Spiroconnected N-alkoxyalkylpiperidine hydantoins were obtained via the Strecker reaction of cyanohydrin with ammonium carbonate. 1,3,8-Triazaspiro[4.5]decane-2,4-diones have shown the myelostimulating activity in the artificially induced (with cyclophosphamide) myelodepressive syndrome. The compoun...

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Bibliographic Details
Main Authors:	Valentina Yu, Assel Ten, Lyailya Baktybayeva, Indira Sagatbekova, Kaldybay Praliyev, Darya Zolotareva, Tulegen Seilkhanov, Alexey Zazybin
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2018/7346835

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