Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Abstract Background and aims Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. Stimulation of the CD40 pathway to initiate anti-tumor immunity...

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Bibliographic Details
Main Authors: A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog, G. Ullenhag
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Translational Medicine
Subjects:
AdCD40L
Malignant melanoma
Immunotherapy
Proteomics
T regulatory cells
Myeloid-derived suppressor cells
Online Access:http://link.springer.com/article/10.1186/s12967-017-1182-z

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http://link.springer.com/article/10.1186/s12967-017-1182-z

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